American journal of ophthalmology case reports · 2017
Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Velez Gabriel, Roybal C Nathaniel, Binkley Elaine, Bassuk Alexander G, Tsang Stephen H, Mahajan Vinit B
Аннотация
PURPOSE: To report a case of elevated intraocular pressure with retinal detachment.
OBSERVATIONS: Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology.
CONCLUSIONS AND IMPORTANCE: Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.
OBSERVATIONS: Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology.
CONCLUSIONS AND IMPORTANCE: Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.