Nuclear medicine communications · 2010
Nasopharyngeal carcinoma: relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification.
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Chan Winnie K S, Mak Henry K F, Huang Bingsheng, Yeung David W C, Kwong Dora Lai-Wan, Khong Pek-Lan
Аннотация
PURPOSE: We aimed to evaluate the relationships between primary tumour; maximum standardized uptake value (SUVmax), metabolic tumour volume (TV) and total lesion glycolysis (TLG) and tumour-node metastases (TNM) classification in nasopharyngeal carcinoma (NPC) patients.
METHODS: Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scans of 57 consecutive newly diagnosed NPC patients (age range, 15-80 years) were retrospectively reviewed. SUVmax, TV and TLG were recorded. Two-tailed Spearman's correlation was used to analyse the relationships between the metabolic parameters and the TNM staging system.
RESULTS: Positive correlations were observed between SUVmax (P<0.001, R=0.516), TV (P<0.001, R=0.504) and TLG (P<0.001, R=0.620) and T-stage, and both TV and SUVmax were independent variables that significantly affected T-stage (P<0.001, adjusted R=0.370). No other significant correlations were found between the metabolic parameters and TNM classification system.
CONCLUSION: The metabolic parameters derived from fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography were positively correlated with T-stage in primary NPC. Our findings may suggest a complementary role of these parameters to TNM staging in prognostication of NPC patients.
METHODS: Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scans of 57 consecutive newly diagnosed NPC patients (age range, 15-80 years) were retrospectively reviewed. SUVmax, TV and TLG were recorded. Two-tailed Spearman's correlation was used to analyse the relationships between the metabolic parameters and the TNM staging system.
RESULTS: Positive correlations were observed between SUVmax (P<0.001, R=0.516), TV (P<0.001, R=0.504) and TLG (P<0.001, R=0.620) and T-stage, and both TV and SUVmax were independent variables that significantly affected T-stage (P<0.001, adjusted R=0.370). No other significant correlations were found between the metabolic parameters and TNM classification system.
CONCLUSION: The metabolic parameters derived from fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography were positively correlated with T-stage in primary NPC. Our findings may suggest a complementary role of these parameters to TNM staging in prognostication of NPC patients.