Frontiers in endocrinology · 2024
The causal relationship between 5 serum lipid parameters and diabetic nephropathy: a Mendelian randomization study.
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Liu Hongzhou, Yao Xinxia, Wang Linlin, Liu Jia, Li Xiaojing, Fu Xiaomin, Liu Jing, Dong Song, Wang Yuhan
Аннотация
BACKGROUND: Serum lipids were found to be correlated with chronic kidney disease and cardiovascular disease. Here, we aimed to research the potential causal associations between five serum lipid parameters and the risk of diabetic nephropathy using several Mendelian Randomization methods.
METHODS: Genetic data was obtained from the UK Biobank datasets. Causal effects were estimated using multiple MR methods. Heterogeneity and pleiotropy tests were performed.
RESULTS: MR analysis revealed that HDL-C and TG exhibited causal associations with diabetic nephropathy (P<0.05). Similar trends were not observed for other lipid parameters.
CONCLUSIONS: Our research has suggested links between HDL-C, TG and diabetic nephropathy. The findings could contribute to further elucidation of the disease etiology.
STRENGTHS AND LIMITATIONS OF THIS STUDY: This article only uses Mendel randomization method to analyze the relationship between blood lipids and diabetes nephropathy, which is more convincing when combined with population data.
METHODS: Genetic data was obtained from the UK Biobank datasets. Causal effects were estimated using multiple MR methods. Heterogeneity and pleiotropy tests were performed.
RESULTS: MR analysis revealed that HDL-C and TG exhibited causal associations with diabetic nephropathy (P<0.05). Similar trends were not observed for other lipid parameters.
CONCLUSIONS: Our research has suggested links between HDL-C, TG and diabetic nephropathy. The findings could contribute to further elucidation of the disease etiology.
STRENGTHS AND LIMITATIONS OF THIS STUDY: This article only uses Mendel randomization method to analyze the relationship between blood lipids and diabetes nephropathy, which is more convincing when combined with population data.