Journal of surgical oncology · 2018
Subungual melanoma: A retrospective cohort of 157 cases from Brazilian National Cancer Institute.
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Nunes Luiz Fernando, Mendes Gélcio L Q, Koifman Rosalina J
Аннотация
BACKGROUND: Subungual melanoma (SM) is rare. The lesions are thick at the time of diagnosis. Few studies have evaluated SM in Brazil.
OBJECTIVE: The objective of this study was to investigate the factors associated with the survival of SM patients from the Brazilian National Cancer Institute.
METHODS: One-hundred and fifty-seven patients diagnosed with SM were included in this study. We evaluated the epidemiologic, clinical, and histopathological data. Overall survival (OS) and relapse-free survival (RFS) curves were computed using the Kaplan-Meier method. Multivariable analyses were conducted using the Cox proportional hazard regression model.
RESULTS: Among the 157 patients, 87 (55.4%) were female. The median age was 68 years old. Median tumor depth was 6.0 mm. Lesions were ulcerated in 94 (59.9%). OS and RFS rates for 5 years were 61.0% and 41.8%, respectively. Median follow-up time was 28 months. The factors associated with OS were Breslow thickness and ulceration, and for RFS, they were the anatomical site, Breslow thickness, and ulceration.
CONCLUSION: This is the largest series of SM patients. The 5-year OS and RFS rates were low (61.0% and 48.2%, respectively), and the main prognostic factors for OS were Breslow thickness and ulceration.
OBJECTIVE: The objective of this study was to investigate the factors associated with the survival of SM patients from the Brazilian National Cancer Institute.
METHODS: One-hundred and fifty-seven patients diagnosed with SM were included in this study. We evaluated the epidemiologic, clinical, and histopathological data. Overall survival (OS) and relapse-free survival (RFS) curves were computed using the Kaplan-Meier method. Multivariable analyses were conducted using the Cox proportional hazard regression model.
RESULTS: Among the 157 patients, 87 (55.4%) were female. The median age was 68 years old. Median tumor depth was 6.0 mm. Lesions were ulcerated in 94 (59.9%). OS and RFS rates for 5 years were 61.0% and 41.8%, respectively. Median follow-up time was 28 months. The factors associated with OS were Breslow thickness and ulceration, and for RFS, they were the anatomical site, Breslow thickness, and ulceration.
CONCLUSION: This is the largest series of SM patients. The 5-year OS and RFS rates were low (61.0% and 48.2%, respectively), and the main prognostic factors for OS were Breslow thickness and ulceration.