The Journal of dermatological treatment · 2018
Fractional carbon dioxide laser assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Abd El-Aal Essam Bakr, Abdo Hamed Mohamed, Ibrahim Shady Mahmoud, Eldestawy Mostafa Taha
Аннотация
BACKGROUND: Onychomycosis is a chronic fungal infection of the nails, and the treatment has been proven to be a challenge to healthcare professionals.
OBJECTIVE: To evaluate the efficacy of fractional carbon dioxide laser-assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
MATERIALS AND METHODS: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, and both groups were treated with four sessions of fractional CO2 laser and followed by topical tazarotene 0.1% in Group A and topical tioconazole 28% in Group B. The clinical effect, KOH examination, and culture for the affected nails in the two groups were analyzed.
RESULTS: One month after the last session, regarding clinical response, 35.3% showed complete improvement in Group A versus 33.3% in Group B without significant difference. There was a significant difference between the two studied groups as regards KOH test and culture result before and after treatment (p value<.001), they were turned negative in 91.7% and 100% of patients in Group A and 78.3% and 95.5% of patients in Group B, respectively.
CONCLUSION: Fractional CO2 laser-assisted drug delivery is an effective and safe treatment option for onychomycosis.
OBJECTIVE: To evaluate the efficacy of fractional carbon dioxide laser-assisted delivery of topical tazarotene versus topical tioconazole in the treatment of onychomycosis.
MATERIALS AND METHODS: A total of 102 patients with onychomycosis were randomly assigned to groups A and B, and both groups were treated with four sessions of fractional CO2 laser and followed by topical tazarotene 0.1% in Group A and topical tioconazole 28% in Group B. The clinical effect, KOH examination, and culture for the affected nails in the two groups were analyzed.
RESULTS: One month after the last session, regarding clinical response, 35.3% showed complete improvement in Group A versus 33.3% in Group B without significant difference. There was a significant difference between the two studied groups as regards KOH test and culture result before and after treatment (p value<.001), they were turned negative in 91.7% and 100% of patients in Group A and 78.3% and 95.5% of patients in Group B, respectively.
CONCLUSION: Fractional CO2 laser-assisted drug delivery is an effective and safe treatment option for onychomycosis.