Respiratory physiology & neurobiology · 2022
Simvastatin attenuates inflammatory process on LPS-induced acute lung injury in mice.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Haute Gabriela Viegas, Luft Carolina, Pedrazza Leonardo, Antunes Géssica Luana, Silveira Josiane, de Souza Basso Bruno, Levorse Vitor Giancarlo Schneider, Bastos Matheus Scherer, Melo Denizar, Rodrigues Ketlin Fernanda, Garcia Maria Claudia, da Costa Mariana Severo, Matzenbacher Lucas Strassburger, Kaiber Daniela Benvenutti, Donadio Márcio Vinícius Fagundes, Gracia-Sancho Jordi, de Oliveira Jarbas Rodrigues
Аннотация
Acute lung injury (ALI) is a disease of high prevalence and is characterized by the excessive production of inflammatory mediators in the lungs of people sick. Inflammation is the major characteristic of ALI and studies report that inhibition of inflammatory cytokines could be an alternative treatment. Statins such as Simvastatin (SV) are known to their use for cholesterol reduction but also for inflammatory and immunoregulatory processes. In this study, we evaluated the effects of SV on LPS-induced alveolar macrophages and in ALI mice model. Our study has demonstrated the protective effects of SV on LPS-activated alveolar macrophages RAW 264.7 and LPS-induced ALI in mice. SV treatment significantly inhibited the alveolar macrophages activation by decreasing the iNOS, IL-1β, and IL-6 gene expression in vitro and in vivo. The treatment also decreased the inflammatory cells migration and the cytokines gene expression. Our findings suggest that SV can act as an anti-inflammatory agent for acute lung injury.