Dermatology (Basel, Switzerland) · 2001
Anti-irritative effect of methylrosaniline chloride (Gentian violet).
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Gloor M, Wolnicki D
Аннотация
BACKGROUND: There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the New German Formulary. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans.
OBJECTIVE: To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis.
METHODS: The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss).
RESULTS: MRC produced significant reductions in all three SLS exposure effects.
CONCLUSIONS: Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound's established antimicrobial activity, but also because of its anti-irritative effect.
OBJECTIVE: To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis.
METHODS: The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss).
RESULTS: MRC produced significant reductions in all three SLS exposure effects.
CONCLUSIONS: Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound's established antimicrobial activity, but also because of its anti-irritative effect.