Medical molecular morphology · 2019
Primary mediastinal large B cell lymphoma with coexisting aberrations of C-MYC and BCL-2: a case report and literature review.
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Jiang Yanyan, Mo Wenbin, Miao Yuan, Liang Ying, Li Yan, Zhang Rui
Аннотация
Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive lymphoma characteristic with distinct clinical, morphologic, and immunophenotypic features. The rearrangements of C-MYC, BCL2 and/or BCL6 which are common in diffuse large B-cell lymphoma (DLBCL) are typically absent in PLMBCL. Here we proved a novel case of PMLBCL with concurrent rearrangements of C-MYC and BCL2. Histology showed typical pathomorphological features of PLMBCL. Fluorescent in situ hybridization (FISH) studies showed rearrangements of C-MYC and copy number variation (CNV) of BCL2 gene. It is not well known on the clinical significance of rearrangements of C-MYC and BCL2 genes in PMLBCL. The case gives evidence that cytogenetic testing is necessary for PMLBCLs to get precise clinical evaluation and appropriate treatment.
Предметные рубрики MeSH
Antineoplastic Combined Chemotherapy ProtocolsBiopsy, Large-Core NeedleCombined Modality TherapyDNA Copy Number VariationsGene RearrangementHumansLung NeoplasmsLymphoma, Large B-Cell, DiffuseMaleMediastinal NeoplasmsMediastinumPositron Emission Tomography Computed TomographyProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycStem Cell TransplantationTransplantation, AutologousTreatment OutcomeYoung Adult