Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010
Evolving classification systems for cancer cachexia: ready for clinical practice?
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Blum David, Omlin Aurelius, Fearon Ken, Baracos Vickie, Radbruch Lukas, Kaasa Stein, Strasser Florian, European Palliative Care Research Collaborative
Аннотация
INTRODUCTION: Involuntary weight loss, the defining factor of cachexia, is a common consequence of advanced cancer.
DISCUSSION: This review summarizes the actual cachexia definitions and classification systems (NCCTG-studies, Loprinzi et al.; PG-SGA, Ottery et al.; Cachexia Consensus Conference, Evans et al; Cancer Cachexia Study Group, Fearon et al.; and SCRINIO Working group, Bozzetti et al.).We describe the ongoing development of a new classification system for cancer cachexia, which is based on literature reviews and Delphi processes within the European Palliative Care Research Collaborative. The review describes the evolving understanding of the pathophysiological mechanisms of cachexia and outlines an overview on treatment options.
CONCLUSION: In this review an outlook on the requirements of a new decision guiding instrument is given and the challenges in clinical decision making in palliative are discussed.
DISCUSSION: This review summarizes the actual cachexia definitions and classification systems (NCCTG-studies, Loprinzi et al.; PG-SGA, Ottery et al.; Cachexia Consensus Conference, Evans et al; Cancer Cachexia Study Group, Fearon et al.; and SCRINIO Working group, Bozzetti et al.).We describe the ongoing development of a new classification system for cancer cachexia, which is based on literature reviews and Delphi processes within the European Palliative Care Research Collaborative. The review describes the evolving understanding of the pathophysiological mechanisms of cachexia and outlines an overview on treatment options.
CONCLUSION: In this review an outlook on the requirements of a new decision guiding instrument is given and the challenges in clinical decision making in palliative are discussed.