Proceedings of the National Academy of Sciences of the United States of America · 2020
Haplotype networks of SARS-CoV-2 infections in the Diamond Princess cruise ship outbreak.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Sekizuka Tsuyoshi, Itokawa Kentaro, Kageyama Tsutomu, Saito Shinji, Takayama Ikuyo, Asanuma Hideki, Nao Naganori, Tanaka Rina, Hashino Masanori, Takahashi Takuri, Kamiya Hajime, Yamagishi Takuya, Kakimoto Kensaku, Suzuki Motoi, Hasegawa Hideki, Wakita Takaji, Kuroda Makoto
Аннотация
The Diamond Princess cruise ship was put under quarantine offshore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR+ clinical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G11083T, suggesting that SARS-CoV-2 dissemination on the Diamond Princess originated from a single introduction event before the quarantine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cabins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.