Posterior Capsular Opacification and Glistening in Hydrophobic Monofocal Biaspheric Intraocular Lens Two Years After Implantation: A Case Control Study.

Background: This study aims to analyze the prevalence and severity of posterior capsule opacification (PCO) and glistening in a new hydrophobic biaspheric monofocal intraocular lens (IOLs) 24 months after implantation. Methods: By means of a ambispective, observational, case-control design, a total of 297 eyes from 200 cataract surgery patients were included in the study (118 females and 82 males; mean age: 72.31 ± 9.87 years, ranging from 35 to 92) and examined at the Hospital Universitario y Politécnico la Fe, Valencia (Spain). Data corresponding to patients implanted with either Asqelio (Study IOL) or Clareon (Control IOL) monofocal IOLs at least 24 months prior to study visit were analyzed. Prevalence and intensity of PCO and IOL glistening were determined and graded for both groups by a single masked observer. Refractive outcomes by autorefractometry, visual acuity, and wavefront aberrations determined by ray tracing were also measured and compared. Results: Prevalence of PCO in patients implanted with the Study IOL 24 months after implantation was 4.0%, lower than that for the Control IOL. Intensity of PCO in both groups was low. One lens in each group presented a Grade 1 glistening after 24 months from implantation. Differences in visual acuity between Study and Control Groups were not significant (p=0.260 and 0.115 for UDVA and CVA, respectively). Residual spherical aberration was significantly lower in the Study Group than that in the Control Group (p=0.007). Conclusion: Prevalence of PCO was considerably lower for Asqelio IOL than for the Control IOL and reports available in the literature for other hydrophobic IOLs. Prevalence of glistening was minimal in both study and control IOLs. Trial Registration: ClinicalTrials.gov identifier: NCT04971863.