Ocular immunology and inflammation · 2019
Poor Control of Sarcoidosis-Related Panuveitis with an Antibody to IL-23.
Клинический случайПисьмо в редакциюНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Thomas Akshay S, Rosenbaum James T
Аннотация
PURPOSE:: To report a case of uveitis worsening in a patient with sarcoidosis while receiving guselkumab (anti-IL-23) for dermatologic disease.
METHODS:: Case report.
RESULTS:: A 61-year-old gentleman had been diagnosed with plaque psoriasis in his 30s. He had been unsuccessfully treated with multiple conventional immunosuppressive agents as well as biologics. He was subsequently diagnosed with pulmonary sarcoidosis with confirmatory oropharyngeal biopsy. His presumed psoriatic skin lesions were subsequently biopsied and were consistent with cutaneous sarcoidosis. His ocular involvement from sarcoidosis had been minimal, requiring only occasional topical corticosteroids. He was started on the interleukin (IL)-23 inhibitor, guselkumab, for his cutaneous disease. Despite mild improvement in his cutaneous disease, he had a bilateral flare of uveitis requiring oral and topical corticosteroids.
CONCLUSIONS:: IL-23 has been implicated in the pathogenesis of uveitis, but there are limited data supporting efficacy of inhibitors of IL-23 in the management of uveitis.
METHODS:: Case report.
RESULTS:: A 61-year-old gentleman had been diagnosed with plaque psoriasis in his 30s. He had been unsuccessfully treated with multiple conventional immunosuppressive agents as well as biologics. He was subsequently diagnosed with pulmonary sarcoidosis with confirmatory oropharyngeal biopsy. His presumed psoriatic skin lesions were subsequently biopsied and were consistent with cutaneous sarcoidosis. His ocular involvement from sarcoidosis had been minimal, requiring only occasional topical corticosteroids. He was started on the interleukin (IL)-23 inhibitor, guselkumab, for his cutaneous disease. Despite mild improvement in his cutaneous disease, he had a bilateral flare of uveitis requiring oral and topical corticosteroids.
CONCLUSIONS:: IL-23 has been implicated in the pathogenesis of uveitis, but there are limited data supporting efficacy of inhibitors of IL-23 in the management of uveitis.