Veterinary ophthalmology · 2026
Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses.
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод пока не подготовлен
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Diehl Kathryn, Sheridan Colleen, Reed Rachel
Аннотация
OBJECTIVE: To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses.
ANIMAL STUDIED: Horse.
PROCEDURE: This was a masked, randomized, balanced cross-over study of six healthy adult horses. Horses were randomly assigned and received 3 mg/kg CBD in sesame oil or volume matched placebo by mouth once daily for three days. Baseline and daily 4-, 12-, and 24-h post treatment IOPs were measured in triplicate without sedation or eyelid akinesia. Baseline and 24-h post final (day 3) treatment STTs were measured without sedation or eyelid akinesia. After a five-week washout period, horses received the alternate treatment, and measurements were repeated as above.
RESULTS: Overall, there were no clinically relevant differences in IOP with CBD administration. Irrespective of treatment, IOPs were significantly higher in the second treatment period (p = 0.009). There were no differences in STT with CBD administration.
CONCLUSION: Oral CBD administration in healthy horses does not impact rebound tonometry IOP or STT measurements.
ANIMAL STUDIED: Horse.
PROCEDURE: This was a masked, randomized, balanced cross-over study of six healthy adult horses. Horses were randomly assigned and received 3 mg/kg CBD in sesame oil or volume matched placebo by mouth once daily for three days. Baseline and daily 4-, 12-, and 24-h post treatment IOPs were measured in triplicate without sedation or eyelid akinesia. Baseline and 24-h post final (day 3) treatment STTs were measured without sedation or eyelid akinesia. After a five-week washout period, horses received the alternate treatment, and measurements were repeated as above.
RESULTS: Overall, there were no clinically relevant differences in IOP with CBD administration. Irrespective of treatment, IOPs were significantly higher in the second treatment period (p = 0.009). There were no differences in STT with CBD administration.
CONCLUSION: Oral CBD administration in healthy horses does not impact rebound tonometry IOP or STT measurements.