Indian journal of dental research : official publication of Indian Society for Dental Research · 2011
Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: a cell culture study.
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Mathew Deepu George, Skariah K Skariah, Ranganathan Kannan
Аннотация
OBJECTIVE: To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF).
MATERIALS AND METHODS: Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied.
RESULTS: Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls.
CONCLUSION: There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF.
MATERIALS AND METHODS: Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied.
RESULTS: Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls.
CONCLUSION: There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF.