Cell · 2020
Compromised SARS-CoV-2-specific placental antibody transfer.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Atyeo Caroline, Pullen Krista M, Bordt Evan A, Fischinger Stephanie, Burke John, Michell Ashlin, Slein Matthew D, Loos Carolin, Shook Lydia L, Boatin Adeline A, Yockey Laura J, Pepin David, Meinsohn Marie-Charlotte, Nguyen Ngoc Minh Phuong, Chauvin Maeva, Roberts Drucilla, Goldfarb Ilona T, Matute Juan D, James Kaitlyn E, Yonker Lael M, Bebell Lisa M, Kaimal Anjali J, Gray Kathryn J, Lauffenburger Douglas, Edlow Andrea G, Alter Galit
Аннотация
SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Here, we used systems serology to characterize the Fc profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third-trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.