Efficacy of miconazole in experimental keratomycosis.

For the first time comparative efficacy of 1% miconazole in ointment base and drops has been evaluated against Candida, Aspergillus and Fusarium organisms in experimental keratomycosis. The findings of the present study reveal that miconazole in ointment drug delivery system has the advantage of being more effective in healing the fungal ulcers and associated lesions. It requires much less frequent application than drops, a parameter of great importance in improving patient compliance. Miconazole ointment was well tolerated by the rabbit eye and produced no ocular or systemic toxicity. The present study confirms that miconazole is a broad-spectrum antifungal agent and it could be a better alternative to presently available drugs to treat human keratomycosis.