Veterinary dermatology · 2016
Efficacy of fluralaner in 17 dogs with sarcoptic mange.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Romero Camilo, Heredia Rafael, Pineda Jocelyn, Serrano Jonathan A, Mendoza Germán D, Trápala Porfirio, Cordero Alberto M
Аннотация
BACKGROUND: There are few licensed options for the treatment of canine sarcoptic mange.
OBJECTIVE: To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.
ANIMALS: Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings.
METHODS: A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month.
RESULTS: By Day 14 post-treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = -0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14-21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28.
CONCLUSION: Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.
OBJECTIVE: To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.
ANIMALS: Seventeen dogs with a diagnosis of Sarcoptes scabiei based on positive skin scrapings.
METHODS: A single dose of oral fluralaner was administered according to the manufacturer's instructions. Assessments of pruritus and lesions were performed every 7 days for 1 month.
RESULTS: By Day 14 post-treatment, skin scrapings from all dogs were negative for mites. At the beginning of the study there was a negative correlation between body weight of the subject and pruritus [Pearson correlation coefficient (PCC) = -0.396, P = 0.007] and a positive correlation between pruritus and lesion severity (PCC 0.755, P = 0.0001). Significant decreases in lesion size and pruritus were observed within the first 14-21 days, respectively, and improvement in these parameters continued until the end of the study at Day 28.
CONCLUSION: Fluralaner was effective in eliminating scabies mites within 14 days and significantly resolved the clinical signs associated with sarcoptic mange within 21 days after a single dose.