Head & neck · 2025
Exploring Quantitative MRI Biomarkers of Head and Neck Post-Radiation Lymphedema and Fibrosis: Post Hoc Analysis of a Prospective Trial.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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MD Anderson Head and Neck Cancer Symptom Working Group, Mao Shitong, Wang Jihong, McMillan Holly, Mohamed Abdallah Sherif Radwan, Buoy Sheila, Ahmed Sara, Mulder Samuel L, Naser Mohamed A, He Renjie, Wahid Kareem A, Chen Melissa Mei, Ding Yao, Moreno Amy C, Lai Stephen Y, Fuller Clifton David, Hutcheson Katherine Arnold
Аннотация
BACKGROUND: Quantifying head and neck lymphedema and fibrosis (HN-LEF) is crucial in the investigation and management of treatment sequelae in head and neck cancer (HNC).
METHODS: The T1- and T2-weighted MRI signal intensity (SI) was examined in relation to HN-LEF categories per physical/tactile examination (No-LEF, A-B = edema, C = edema + fibrosis, D = fibrosis), and MRI structural volumes were examined in relation to a novel 10-point HN-LEF score in the intraoral and submental regions.
RESULTS: We identified differences in ranks among HN-LEF categories in relation to the MRI SI (A-B and C are higher than D and No-LEF for T2 SI, and A-B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (p < 0.05) with the HN-LEF score at adjacent palpable sites.
CONCLUSION: Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.
METHODS: The T1- and T2-weighted MRI signal intensity (SI) was examined in relation to HN-LEF categories per physical/tactile examination (No-LEF, A-B = edema, C = edema + fibrosis, D = fibrosis), and MRI structural volumes were examined in relation to a novel 10-point HN-LEF score in the intraoral and submental regions.
RESULTS: We identified differences in ranks among HN-LEF categories in relation to the MRI SI (A-B and C are higher than D and No-LEF for T2 SI, and A-B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (p < 0.05) with the HN-LEF score at adjacent palpable sites.
CONCLUSION: Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.