Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2011
Lack of association between eotaxin-1 gene polymorphisms and nasal polyposis.
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Ekinci Suna, Erbek Selim S, Yurtcu Erkan, Sahin Feride I
Аннотация
OBJECTIVE: To examine whether there is an association of eotaxin-1 gene polymorphisms with nasal polyposis (NP).
STUDY DESIGN: Cross-sectional study.
SETTING: Tertiary referral center.
SUBJECTS AND METHODS: The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin-1 (-384 A>G and +67 G>A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
RESULTS: The -384 A>G and +67 G>A single nucleotide polymorphisms were higher in patients with NP than in controls (P = .044 and P = .019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (-384 A>G, P = .164; +67 G>A, P = .144).
CONCLUSION: In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to NP.
STUDY DESIGN: Cross-sectional study.
SETTING: Tertiary referral center.
SUBJECTS AND METHODS: The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin-1 (-384 A>G and +67 G>A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
RESULTS: The -384 A>G and +67 G>A single nucleotide polymorphisms were higher in patients with NP than in controls (P = .044 and P = .019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (-384 A>G, P = .164; +67 G>A, P = .144).
CONCLUSION: In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to NP.