Lack of association between eotaxin-1 gene polymorphisms and nasal polyposis.

OBJECTIVE

To examine whether there is an association of eotaxin-1 gene polymorphisms with nasal polyposis (NP).

STUDY

DESIGN

Cross-sectional study.

SETTING

Tertiary referral center.

SUBJECTS AND

METHODS

The study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin-1 (-384 A>G and +67 G>A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.

RESULTS

The -384 A>G and +67 G>A single nucleotide polymorphisms were higher in patients with NP than in controls (P = .044 and P = .019, respectively). However, their relation was statistically poor (association coefficient = 0.18). Consistent with this result, comparisons of allele frequencies for both single nucleotide polymorphisms were not significantly different (-384 A>G, P = .164; +67 G>A, P = .144).

CONCLUSION

In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to NP.