[Impact of Seasonal Climate Variations on Skin Toxicity Induced by Anti-EGFR Antibody Therapy in Patients with Metastatic Colorectal Cancer].

Skin-related adverse events(AEs)are a major adverse effect of anti-EGFR antibody therapy in metastatic colorectal cancer.While various preventive skincare strategies have been reported, few studies have examined the relationship between skin-related AEs and seasonal variations.We retrospectively analyzed 73 patients who received anti-EGFR antibody therapy at Hyogo Medical University Hospital from January 2020 to August 2023.The primary endpoint was the incidence of Grade≥2 skin-related AEs at weeks 8 and 12 after treatment initiation in the summer(Su group)and winter(Wi group)groups, compared to the spring/autumn(Control group).At week 12, the Wi group had a significantly higher incidence of skin-related AEs than the Control group(94.4% vs 61.1%, p=0.011).No significant differences were observed for rash acneiform or paronychia, but Grade≥2 dry skin was significantly more frequent in the Wi group(83.3% vs 50.0%, p=0.021).Younger age(<65 years)(HR: 1.94, 95%CI: 1.18-3.21, p=0.009)and treatment initiation in winter(HR: 2.04, 95%CI: 1.11-3.76, p=0.022)were identified as risk factors.These findings suggest that patients initiating treatment in winter may be at increased risk of severe dry skin, necessitating enhanced skincare measures.