The immunoglobulins in Aleutian disease (viral plasmacytosis) of mink. Different types of hypergammaglobulinemias.

Mink infected with the aleutian disease virus developed different types of hypergammaglobulinemias according to the incidence of immunoglobulin classes. Usually, increases of immunoglobulin in serum of infected mink occurred over a broad spectrum as a general increase in the immunoglobulins. In some infected animals a predominantly selective increase was demonstrated with only certain immunoglobulin classes being present at elevated levels. Selective increases of immunoglobulin classes were observed as early as 35 days post-infection. The inoculum in experimental infection did not control or determine the type of immunoglobulin pattern which developed in the infected mink. The immunoglobulin pattern in the donor of the inoculum had no bearing on the immunglobulin pattern which developed in the recipient, infected animal.