Journal of women's health (2002) · 2009
Mechanisms of sex difference: a historical perspective.
Историческая статьяСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Seeman Mary V
Аннотация
OBJECTIVE: The history of the discovery of mechanisms contributing to sex difference helps to better appreciate gender factors in a variety of disease states. The objective of this article is to illustrate four mechanisms of sex differences in disease incidence: X-linkage (including inactivation, escape from inactivating, skewed inactivation), sex-specific exposure to disease-producing pathogens, fetal microchimerism, and iron depletion.
METHODS: This is a historic review.
RESULTS: An emphasis on sex difference led to the uncovering of four different mechanisms by which illness rates differ in men and women.
CONCLUSIONS: Research into many disease states can benefit from a focus on potential mechanisms that yield sex differences in illness susceptibility, progression, and outcome.
METHODS: This is a historic review.
RESULTS: An emphasis on sex difference led to the uncovering of four different mechanisms by which illness rates differ in men and women.
CONCLUSIONS: Research into many disease states can benefit from a focus on potential mechanisms that yield sex differences in illness susceptibility, progression, and outcome.