Neuroimmunomodulation · 2019
Plasma Homocysteine Level Is Associated with the Expanded Disability Status Scale in Neuromyelitis Optica Spectrum Disorder.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Liang Jie, Liu Jia, Fan Rong, Chen Zhigang, Chen Xiaohong, Tong Jiayi, Chen Yong, Peng Fuhua, Jiang Ying
Аннотация
BACKGROUND AND OBJECTIVE: Plasma homocysteine (Hcy) levels have been investigated among patients with multiple sclerosis (MS). However, the changes in Hcy levels and the association between Hcy levels and inflammatory/immune/cerebrospinal fluid (CSF) parameters in neuromyelitis optica spectrum disorder (NMOSD) patients have not been investigated yet.
METHODS: Case data were collected from 97 acute-phase NMOSD patients and 39 stable-phase NMOSD patients. Patients in the acute phase were divided into 2 groups based on the EDSS score with cutoff equal to 4. Hcy levels, immunoglobulins (Ig) A, G, and M, complement 3 and 4, CH50, C-reactive protein, erythrocyte sedimentation rate (ESR), and CSF examination including white blood cells and total protein were determined.
RESULTS: No significant differences in Hcy levels are observed between acute-phase and stable-phase NMOSD patients. Hcy and ESR levels were significantly higher in acute-phase NMOSD patients with EDSS score ≥4. Besides, EDSS is positively correlated with Hcy level, ESR, 1/aquaporin-4 titer and Hcy level is negatively correlated with IgM in acute-phase NMOSD patients.
CONCLUSION: Elevated plasma Hcy has the potential to affect the pathogenesis or progression of NMOSD.
METHODS: Case data were collected from 97 acute-phase NMOSD patients and 39 stable-phase NMOSD patients. Patients in the acute phase were divided into 2 groups based on the EDSS score with cutoff equal to 4. Hcy levels, immunoglobulins (Ig) A, G, and M, complement 3 and 4, CH50, C-reactive protein, erythrocyte sedimentation rate (ESR), and CSF examination including white blood cells and total protein were determined.
RESULTS: No significant differences in Hcy levels are observed between acute-phase and stable-phase NMOSD patients. Hcy and ESR levels were significantly higher in acute-phase NMOSD patients with EDSS score ≥4. Besides, EDSS is positively correlated with Hcy level, ESR, 1/aquaporin-4 titer and Hcy level is negatively correlated with IgM in acute-phase NMOSD patients.
CONCLUSION: Elevated plasma Hcy has the potential to affect the pathogenesis or progression of NMOSD.
Предметные рубрики MeSH
AdultAquaporin 4AutoantibodiesBlood SedimentationC-Reactive ProteinCerebrospinal FluidCerebrospinal Fluid ProteinsComplement C3Complement C4Complement Hemolytic Activity AssayDisease ProgressionFemaleHomocysteineHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MLeukocyte CountMaleMiddle AgedNeuromyelitis OpticaSeverity of Illness Index