Neurobiology of aging · 2016
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Gan-Or Ziv, Montplaisir Jacques Y, Ross Jay P, Poirier Judes, Warby Simon C, Arnulf Isabelle, Strong Stephanie, Dauvilliers Yves, Leblond Claire S, Hu Michele T M, Högl Birgit, Stefani Ambra, Monaca Christelle Charley, De Cock Valérie Cochen, Boivin Michel, Ferini-Strambi Luigi, Plazzi Giuseppe, Antelmi Elena, Young Peter, Heidbreder Anna, Barber Thomas R, Evetts Samuel G, Rolinski Michal, Dion Patrick A, Desautels Alex, Gagnon Jean-François, Dupré Nicolas, Postuma Ronald B, Rouleau Guy A
Аннотация
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.