The Journal of infectious diseases · 2019
A Systematic Phylogenetic Approach to Study the Interaction of HIV-1 With Coinfections, Noncommunicable Diseases, and Opportunistic Diseases.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kusejko Katharina, Bachmann Nadine, Chaudron Sandra E, Nguyen Huyen, Braun Dominique L, Hampel Benjamin, Battegay Manuel, Bernasconi Enos, Calmy Alexandra, Cavassini Matthias, Hoffmann Matthias, Böni Jürg, Yerly Sabine, Klimkait Thomas, Perreau Matthieu, Rauch Andri, Günthard Huldrych F, Kouyos Roger D, Swiss HIV Cohort Study
Аннотация
To systematically test whether coinfections spread along the HIV-1 transmission network and whether similarities in HIV-1 genomes predict AIDS-defining illnesses and comorbidities, we analyzed the distribution of these variables on the HIV phylogeny of the densely sampled Swiss HIV Cohort Study. By combining different statistical methods, we could detect, quantify, and explain the clustering of diseases. Infectious conditions such as hepatitis C, but also Kaposi sarcoma, clustered significantly, suggesting transmission of these infections along the HIV-1 transmission network. The clustering of patients with neurocognitive complaints could not be completely explained by the clustering of patients with similar demographic risk factors, which suggests a potential impact of viral genetics. In summary, the consistent and robust signal for coinfections and comorbidities highlights the strong interaction of HIV-1 and other infections and shows the potential of combining phylogenetic methods to identify disease traits that are likely to be related to virus genetic factors.