BMJ (Clinical research ed.) · 2003
Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India.
Клиническое исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Rahmathullah Lakshmi, Tielsch James M, Thulasiraj R D, Katz Joanne, Coles Christian, Devi Sheela, John Rajeesh, Prakash Karthik, Sadanand A V, Edwin N, Kamaraj C
Аннотация
OBJECTIVE: To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months.
DESIGN: Community based, randomised, double blind, placebo controlled trial.
SETTING: Two rural districts of Tamil Nadu, southern India.
PARTICIPANTS: 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.
MAIN OUTCOME MEASURE: Primary outcome measure was mortality at age 6 months.
RESULTS: Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.
CONCLUSION: Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.
DESIGN: Community based, randomised, double blind, placebo controlled trial.
SETTING: Two rural districts of Tamil Nadu, southern India.
PARTICIPANTS: 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after delivery.
MAIN OUTCOME MEASURE: Primary outcome measure was mortality at age 6 months.
RESULTS: Infants in the vitamin A group had a 22% reduction in total mortality (95% confidence interval 4% to 37%) compared with those in the placebo group. Vitamin A had an impact on mortality between two weeks and three months after treatment, with no additional impact after three months.
CONCLUSION: Supplementing newborn infants with vitamin A can significantly reduce early infant mortality.