Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.
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Sakurai Keita, Tokumaru Aya M, Yoshida Mari, Saito Yuko, Wakabayashi Koichi, Komori Takashi, Hasegawa Masato, Ikeuchi Takeshi, Hayashi Yuichi, Shimohata Takayoshi, Murayama Shigeo, Iwasaki Yasushi, Uchihara Toshiki, Sakai Motoko, Yabe Ichiro, Tanikawa Satoshi, Takigawa Hiroshi, Adachi Tadashi, Hanajima Ritsuko, Fujimura Harutoshi, Hayashi Kentaro, Sugaya Keizo, Hasegawa Kazuko, Sano Terunori, Takao Masaki, Yokota Osamu, Miki Tomoko, Kobayashi Michio, Arai Nobutaka, Ohkubo Takuya, Yokota Takanori, Mori Keiko, Ito Masumi, Ishida Chiho, Idezuka Jiro, Toyoshima Yasuko, Kanazawa Masato, Aoki Masashi, Hasegawa Takafumi, Watanabe Hirohisa, Hashizume Atsushi, Niwa Hisayoshi, Yasui Keizo, Ito Keita, Washimi Yukihiko, Kubota Akatsuki, Toda Tatsushi, Nakashima Kenji, Aiba Ikuko, J-VAC study group
Аннотация
METHODS: Semiquantitative visual rating scales were employed to assess the degree and distribution of atrophy and asymmetry on conventional T1-weighted and T2-weighted images. Additionally, subcortical white matter hyperintensity (SWMH) on fluid-attenuated inversion recovery images were visually evaluated.
RESULTS: In addition to 19 patients with CBD, 16 with CBD mimics (progressive supranuclear palsy (PSP): 9, Alzheimer's disease (AD): 4, dementia with Lewy bodies (DLB): 1, frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa(FTLD-TDP): 1, and globular glial tauopathy (GGT): 1) were investigated. Compared with the CBD group, the PSP-CBS subgroup showed severe midbrain atrophy without SWMH. The non-PSP-CBS subgroup, comprising patients with AD, DLB, FTLD-TDP, and GGT, showed severe temporal atrophy with widespread asymmetry, especially in the temporal lobes. In addition to over half of the patients with CBD, two with FTLD-TDP and GGT showed SWMH, respectively.
CONCLUSION: This study elucidates the distinct structural changes between the CBD and its mimics based on visual rating scales. The evaluation of atrophic distribution and SWMH may serve as imaging biomarkers of conventional MRI for detecting background pathologies.