Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina · 2013
Spatial tuning function of pattern visual evoked potentials in multiple sclerosis patients without optic neuritis history.
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Taş Ahmet, Cakir Gundogan Fatih, Akgun Hakan, Erdem Uzeyir, Sobaci Gungor
Аннотация
AIM: To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without optic neuritis history.
METHODS: Thirty-six MS patients and 21 control subjects were included. Pattern visual evoked responses to ive check sizes (2°, 1°, 30', 15', and 7') were recorded.
RESULTS: P100 amplitudes were significantly reduced in 2°, 1° and 7' checks and, P100 latencies were significantly delayed in all checks in MS patients (p < 0.05). Inter-ocular amplitude/ latency differences were significantly higher in MS patients than control group (p < 0.05). The P100 amplitudes for 2° check was somewhat higher than amplitudes for 1° check in MS and control groups. However, MS patients had latter amplitude-check size function curve in large checks. In small checks, the slope of the amplitude-check size curves were similar for MS and control groups. The flattening of amplitude-check size function curve in large checks increased in MS patients with reduced P100 amplitudes. The P100 amplitudes for 2° check was lower than P100 amplitudes for 1° check in MS patients with reduced P100 amplitudes in contrast to normal subjects and MS patients with normal P100 amplitudes. Both groups had almost parallel P100 latency-check size curves in all checks. With respect to 95% confidence limit in control subjects in each check sizes, the number of eyes with delayed latency and reduced amplitude in MS patients were higher in large checks.
CONCLUSION: This study showed that P100 amplitudes are reduced in MS patients without optic neuritis history, and responses to large checks are affected more than small checks.
METHODS: Thirty-six MS patients and 21 control subjects were included. Pattern visual evoked responses to ive check sizes (2°, 1°, 30', 15', and 7') were recorded.
RESULTS: P100 amplitudes were significantly reduced in 2°, 1° and 7' checks and, P100 latencies were significantly delayed in all checks in MS patients (p < 0.05). Inter-ocular amplitude/ latency differences were significantly higher in MS patients than control group (p < 0.05). The P100 amplitudes for 2° check was somewhat higher than amplitudes for 1° check in MS and control groups. However, MS patients had latter amplitude-check size function curve in large checks. In small checks, the slope of the amplitude-check size curves were similar for MS and control groups. The flattening of amplitude-check size function curve in large checks increased in MS patients with reduced P100 amplitudes. The P100 amplitudes for 2° check was lower than P100 amplitudes for 1° check in MS patients with reduced P100 amplitudes in contrast to normal subjects and MS patients with normal P100 amplitudes. Both groups had almost parallel P100 latency-check size curves in all checks. With respect to 95% confidence limit in control subjects in each check sizes, the number of eyes with delayed latency and reduced amplitude in MS patients were higher in large checks.
CONCLUSION: This study showed that P100 amplitudes are reduced in MS patients without optic neuritis history, and responses to large checks are affected more than small checks.