Internal medicine (Tokyo, Japan) · 2022
Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations.
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Tsuboi Yuri, Sakamoto Tatsuhiro, Makishima Kenichi, Suehara Yasuhito, Hattori Keiichiro, Kurita Naoki, Yokoyama Yasuhisa, Kato Takayasu, Nishikii Hidekazu, Obara Naoshi, Matsumura Fumiaki, Matsuoka Ryota, Chiba Shigeru, Sakata-Yanagimoto Mamiko
Аннотация
Triple-negative essential thrombocythemia (ET) is a condition in which mutations in JAK2, CALR and MPL are all negative. Transformation to acute myeloid leukemia may occur during the course of ET, while B-acute lymphoblastic leukemia B-(ALL) is rare. We experienced a case diagnosed as B-ALL during the course of triple-negative ET. Notably, cytoreduction was required for the excessive increase in blood cells during the bone marrow recovery period after chemotherapies. Whole exome sequencing identified 17 somatic mutations: 9 were identified in both ET and B-ALL samples, while 8 were specific to B-ALL, suggesting that these 8 might have caused the transformation.