Adrenalectomy for solid tumor metastases: results of a multicenter European study.
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Moreno Pablo, de la Quintana Basarrate Aitor, Musholt Thomas J, Paunovic Ivan, Puccini Marco, Vidal Oscar, Ortega Joaquín, Kraimps Jean-Louis, Bollo Arocena Elisabet, Rodríguez José M, González López Oscar, Del Pozo Carlos D, Iacobone Maurizio, Veloso Enrique, Del Pino José M, García Sanz Iñigo, Scott-Coombes David, Villar-Del-Moral Jesús, Rodríguez José I, Vázquez Echarri Jaime, González Sánchez Carmen, Gutiérrez Rodríguez María-Teresa, Escoresca Ignacio, Nuño Vázquez-Garza José, Tobalina Aguirrezábal Ernesto, Martín Jesús, Candel Arenas Mari Fe, Lorenz Kerstin, Martos Juan M, Ramia José M
Аннотация
METHODS: Patients with histologically proven adrenal metastatic disease and undergoing complete removal(s) of the affected gland(s) were eligible.
RESULTS: Non-small cell lung cancer (NSCLC) was the most frequent tumor type followed by colorectal and renal cell carcinoma. Adrenal metastases were synchronous (≤6 months) in 73 (23%) patients and isolated in 213 (67%). The median disease-free interval was 18.5 months. Laparoscopic resection was used in 46% of patients. Surgery was limited to the adrenal gland in 73% of patients and R0 resection was achieved in 86% of cases. The median overall survival was 29 months (95% confidence interval, 24.69-33.30). The survival rates at 1, 2, 3, and 5 years were 80%, 61%, 42%, and 35%, respectively. Patients with renal cancer showed a median survival of 84 months, patients with NSCLC 26 months, and patients with colorectal cancer 29 months (P = .017). Differences in survival between metachronous and synchronous lesions were also significant (30 vs. 23 months; P = .038).
CONCLUSION: Surgical removal of adrenal metastasis is associated with long-term survival in selected patients.