La Revue de medecine interne · 2004
[Bilateral optic neuropathy revealing systemic sarcoidosis].
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Guilpain P, Andreu M A, Cassoux N, Le Thi Huong-Boutin D, Jaeger-Bizet F, Nasica X, Chapelon-Abric C, Wechsler B, Lehoang P, Piette J C
Аннотация
INTRODUCTION: Although ocular involvement concerns about 25 to 60% of patients with systemic sarcoidosis, papilledema is a rare event.
EXEGESIS: A 43-year-old man presented with left visual loss related to papillitis. Despite high-dose corticosteroids, visual loss became rapidly bilateral. Thoracic CT-scan showed mediastinal and parenchymal involvement. Histological study of lung, bronchial and lymphadenopathy biopsies displayed giant-cells granuloma without necrosis. Diagnosis of sarcoidosis complicated with optic neuropathy was made. Therapy combining prednisone, methotrexate and infliximab was started without significant improvement of visual acuity.
CONCLUSION: This report underlines the potential severity of optic neuropathy in sarcoidosis.
EXEGESIS: A 43-year-old man presented with left visual loss related to papillitis. Despite high-dose corticosteroids, visual loss became rapidly bilateral. Thoracic CT-scan showed mediastinal and parenchymal involvement. Histological study of lung, bronchial and lymphadenopathy biopsies displayed giant-cells granuloma without necrosis. Diagnosis of sarcoidosis complicated with optic neuropathy was made. Therapy combining prednisone, methotrexate and infliximab was started without significant improvement of visual acuity.
CONCLUSION: This report underlines the potential severity of optic neuropathy in sarcoidosis.