Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
Relationship between the cumulative exposure to atherogenic index of plasma and new-onset hypertension: a prospective cohort study.
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Qi Qi, Wu Xinyu, Han Quanle, Li Lei, Deng Jie, Jiang Yue, Yu Jing, Wu Shouling, Li Kangbo
Аннотация
BACKGROUND AND AIM: Recent research has shown a significant association between the atherogenic index of plasma (AIP) and hypertension. Nevertheless, it remains unclear whether the cumulative exposure to AIP influence the risk of hypertension. Therefore, we aimed to characterize the relationship between cumulative exposure to AIP and the risk of new-onset hypertension in a general population.
METHODS AND RESULTS: A total of 28,617 individuals sourced from the Kailuan study database were included in this study. Participants were stratified into four groups by the quartiles of cumulative AIP (cumAIP) or the duration of high AIP exposure. The association between the cumulative exposure to AIP and new-onset hypertension was assessed using Cox proportional hazard models by calculating hazard ratios (HRs) and 95 % confidence intervals (95 % CIs). In addition, subgroup analysis was performed after stratification by age, sex, and body mass index (BMI). A total of 13,177 cases of hypertension were recorded during a median follow-up of 11.04 years. Compared to quartile 1, the HRs (95 % CI) of quartiles 2-4 were 1.08 (1.02-1.14), 1.16 (1.10-1.23), and 1.21 (1.13-1.28), respectively. In addition, compared to 0-year high AIP exposure, the HRs (95 % CI) of 2-6 years of high AIP exposure were 1.09 (1.04-1.14), 1.15 (1.09-1.22), and 1.18 (1.10-1.27), respectively. In addition, our results showed that the association between cumulative exposure to AIP and new-onset hypertension was stronger in participants <60 years of age than in participants ≥60 years of age, stronger in females than in males, and stronger in participants with BMI ≥28 than in participants with BMI <28.
CONCLUSIONS: High cumAIP is associated with a higher risk of new-onset hypertension. Maintaining appropriate levels of cumAIP is important for the prevention of hypertension.
METHODS AND RESULTS: A total of 28,617 individuals sourced from the Kailuan study database were included in this study. Participants were stratified into four groups by the quartiles of cumulative AIP (cumAIP) or the duration of high AIP exposure. The association between the cumulative exposure to AIP and new-onset hypertension was assessed using Cox proportional hazard models by calculating hazard ratios (HRs) and 95 % confidence intervals (95 % CIs). In addition, subgroup analysis was performed after stratification by age, sex, and body mass index (BMI). A total of 13,177 cases of hypertension were recorded during a median follow-up of 11.04 years. Compared to quartile 1, the HRs (95 % CI) of quartiles 2-4 were 1.08 (1.02-1.14), 1.16 (1.10-1.23), and 1.21 (1.13-1.28), respectively. In addition, compared to 0-year high AIP exposure, the HRs (95 % CI) of 2-6 years of high AIP exposure were 1.09 (1.04-1.14), 1.15 (1.09-1.22), and 1.18 (1.10-1.27), respectively. In addition, our results showed that the association between cumulative exposure to AIP and new-onset hypertension was stronger in participants <60 years of age than in participants ≥60 years of age, stronger in females than in males, and stronger in participants with BMI ≥28 than in participants with BMI <28.
CONCLUSIONS: High cumAIP is associated with a higher risk of new-onset hypertension. Maintaining appropriate levels of cumAIP is important for the prevention of hypertension.