Progress in cardiovascular diseases · 2025
Handgrip strength asymmetry increases risk of all-cause and cardiovascular mortality: A dose-response analysis across 28 countries.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Polo-López Ana, Andersen Lars Louis, Núñez-Cortés Rodrigo, López-Bueno Rubén, Cruz-Montecinos Carlos, Suso-Martí Luis, Calatayud Joaquín
Аннотация
OBJECTIVE: To examine the association between handgrip strength asymmetry and the risk of all-cause and cardiovascular mortality.
METHODS: This cohort study analyzed participants aged 50 years and older from the SHARE study (2004-2022) across 28 countries. Handgrip strength asymmetry was assessed using a dynamometer, and mortality outcomes (all-cause and cardiovascular) were determined through proxy interviews. Using time-varying Cox regression models, we examined the association between handgrip asymmetry and mortality risk, adjusting for multiple covariates.
RESULTS: The study included 107,256 participants (54.9 % women, 45.1 % men). Over a mean follow-up of 7.3 years, 11,574 deaths (10.8 %) from all causes and 4274 (3.98 %) from cardiovascular causes were recorded. The analysis revealed a non-linear relationship. For handgrip strength asymmetries of 4-5 kg, both all-cause mortality risk (HR: 1.06; 95 % CI: 1.01-1.10) and cardiovascular mortality risk (HR: 1.15; 95 % CI: 1.07-1.24) increased significantly. A more pronounced increase was observed from 10 kg of asymmetry, with a 32 % increased risk of all-cause mortality (HR: 1.32; 95 % CI: 1.22-1.43) and a 39 % increased risk of cardiovascular mortality (HR: 1.39; 95 % CI: 1.22-1.59). For asymmetries ≥15 kg, the risk of all-cause mortality increased by 39 % (HR: 1.39; 95 % CI: 1.19-1.61) and by 58 % for cardiovascular mortality (HR: 1.58; 95 % CI: 1.24-2.02).
CONCLUSIONS: Even minor handgrip strength asymmetry is significantly linked to higher mortality. This finding suggests that handgrip strength asymmetry may have potential clinical relevance as an additional marker for mortality risk assessment, though further research is needed to evaluate its discriminative value beyond established risk factors.
METHODS: This cohort study analyzed participants aged 50 years and older from the SHARE study (2004-2022) across 28 countries. Handgrip strength asymmetry was assessed using a dynamometer, and mortality outcomes (all-cause and cardiovascular) were determined through proxy interviews. Using time-varying Cox regression models, we examined the association between handgrip asymmetry and mortality risk, adjusting for multiple covariates.
RESULTS: The study included 107,256 participants (54.9 % women, 45.1 % men). Over a mean follow-up of 7.3 years, 11,574 deaths (10.8 %) from all causes and 4274 (3.98 %) from cardiovascular causes were recorded. The analysis revealed a non-linear relationship. For handgrip strength asymmetries of 4-5 kg, both all-cause mortality risk (HR: 1.06; 95 % CI: 1.01-1.10) and cardiovascular mortality risk (HR: 1.15; 95 % CI: 1.07-1.24) increased significantly. A more pronounced increase was observed from 10 kg of asymmetry, with a 32 % increased risk of all-cause mortality (HR: 1.32; 95 % CI: 1.22-1.43) and a 39 % increased risk of cardiovascular mortality (HR: 1.39; 95 % CI: 1.22-1.59). For asymmetries ≥15 kg, the risk of all-cause mortality increased by 39 % (HR: 1.39; 95 % CI: 1.19-1.61) and by 58 % for cardiovascular mortality (HR: 1.58; 95 % CI: 1.24-2.02).
CONCLUSIONS: Even minor handgrip strength asymmetry is significantly linked to higher mortality. This finding suggests that handgrip strength asymmetry may have potential clinical relevance as an additional marker for mortality risk assessment, though further research is needed to evaluate its discriminative value beyond established risk factors.