Pathologie (Heidelberg, Germany) · 2025
Taking imaging into the fourth dimension.
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Hansmann Martin-Leo
Аннотация
BACKGROUND: Hematopathology is rapidly advancing. Combining structural, molecular, and dynamic analyses enables a deeper understanding of immune reactions and malignant lymphomas.
MATERIALS AND METHODS: Three-dimensional (3D) imaging uses fluorescence-stained tissue sections with confocal microscopy. Four-dimensional (4D) live tissue slices allow real-time visualization of immune cell movement. Drugs can be tested directly on fresh samples.
RESULTS: Three-dimensional images show key immune cell types; 4D imaging reveals cell-cell interactions. Nivolumab, for example, prolonged T cell contact with Hodgkin cells.
CONCLUSION: Four-dimensional technology improves early disease detection, treatment monitoring, and drug development, bridging between molecular findings and clinical applications.
MATERIALS AND METHODS: Three-dimensional (3D) imaging uses fluorescence-stained tissue sections with confocal microscopy. Four-dimensional (4D) live tissue slices allow real-time visualization of immune cell movement. Drugs can be tested directly on fresh samples.
RESULTS: Three-dimensional images show key immune cell types; 4D imaging reveals cell-cell interactions. Nivolumab, for example, prolonged T cell contact with Hodgkin cells.
CONCLUSION: Four-dimensional technology improves early disease detection, treatment monitoring, and drug development, bridging between molecular findings and clinical applications.