Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996
Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection.
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Fukatsu K, Saito H, Fukushima R, Lin M T, Inoue T, Inaba T, Furukawa S, Han I, Muto T
Аннотация
OBJECTIVE: To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model.
DESIGN: Prospective randomized experimental trials.
SETTING: Laboratory.
SUBJECTS: Female Balb/c mice.
INTERVENTIONS: Escherichia coli (10(8) colony-forming-units/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge.
MEASUREMENTS: One hundred and fifteen animals were observed for survival.
RESULTS: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time after E. coli challenge.
CONCLUSIONS: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.
DESIGN: Prospective randomized experimental trials.
SETTING: Laboratory.
SUBJECTS: Female Balb/c mice.
INTERVENTIONS: Escherichia coli (10(8) colony-forming-units/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge.
MEASUREMENTS: One hundred and fifteen animals were observed for survival.
RESULTS: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time after E. coli challenge.
CONCLUSIONS: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.