Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Dellon Evan S, Liacouras Chris A, Molina-Infante Javier, Furuta Glenn T, Spergel Jonathan M, Zevit Noam, Spechler Stuart J, Attwood Stephen E, Straumann Alex, Aceves Seema S, Alexander Jeffrey A, Atkins Dan, Arva Nicoleta C, Blanchard Carine, Bonis Peter A, Book Wendy M, Capocelli Kelley E, Chehade Mirna, Cheng Edaire, Collins Margaret H, Davis Carla M, Dias Jorge A, Di Lorenzo Carlo, Dohil Ranjan, Dupont Christophe, Falk Gary W, Ferreira Cristina T, Fox Adam, Gonsalves Nirmala P, Gupta Sandeep K, Katzka David A, Kinoshita Yoshikazu, Menard-Katcher Calies, Kodroff Ellyn, Metz David C, Miehlke Stephan, Muir Amanda B, Mukkada Vincent A, Murch Simon, Nurko Samuel, Ohtsuka Yoshikazu, Orel Rok, Papadopoulou Alexandra, Peterson Kathryn A, Philpott Hamish, Putnam Philip E, Richter Joel E, Rosen Rachel, Rothenberg Marc E, Schoepfer Alain, Scott Melissa M, Shah Neil, Sheikh Javed, Souza Rhonda F, Strobel Mary J, Talley Nicholas J, Vaezi Michael F, Vandenplas Yvan, Vieira Mario C, Walker Marjorie M, Wechsler Joshua B, Wershil Barry K, Wen Ting, Yang Guang-Yu, Hirano Ikuo, Bredenoord Albert J
Аннотация
METHODS: A consensus conference was convened to address the issue of PPI use for esophageal eosinophilia using a process consistent with standards described in the Appraisal of Guidelines for Research and Evaluation II. Pediatric and adult physicians and researchers from gastroenterology, allergy, and pathology subspecialties representing 14 countries used online communications, teleconferences, and a face-to-face meeting to review the literature and clinical experiences.
RESULTS: Substantial evidence documented that PPIs reduce esophageal eosinophilia in children, adolescents, and adults, with several mechanisms potentially explaining the treatment effect. Based on these findings, an updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement.
CONCLUSIONS: EoE should be diagnosed when there are symptoms of esophageal dysfunction and at least 15 eosinophils per high-power field (or approximately 60 eosinophils per mm2) on esophageal biopsy and after a comprehensive assessment of non-EoE disorders that could cause or potentially contribute to esophageal eosinophilia. The evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EoE than as a diagnostic criterion, and we have developed updated consensus criteria for EoE that reflect this change.