Radiation therapy and radio-nuclides for palliation of bone pain.

Bone pain from metastatic prostate cancer can be effectively palliated by a single fraction of 8 Gy with no increase in toxicity, which can occur with more protracted fractionation schemes. Re-treatment, if required, is simple and effective. For multiple painful sites on the same side of the diaphragm, hemi-body radiotherapy is rapidly effective; pre-medication with odanstetron and steroids has markedly improved tolerance. For multiple painful sites on both sides of the diaphragm, radiopharmaceuticals can be considered but will not treat adjacent soft tissue disease or neurologic compromise.