Microbiology spectrum · 2023
Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort.
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Rothe Kathrin, Bachfischer Tobias, Karapetyan Siranush, Hapfelmeier Alexander, Wurst Milena, Gleich Sabine, Dichtl Karl, Schmid Roland M, Triebelhorn Julian, Wagner Laura, Erber Johanna, Voit Florian, Burgkart Rainer, Obermeier Andreas, Seibold Ulrich, Busch Dirk H, Rämer Patrick C, Spinner Christoph D, Schneider Jochen
Аннотация
The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli (E. coli) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Enterococcus faecium (ECFM) bloodstream infections, with vancomycin resistance not being a significant contributing factor. Our findings imply that E. faecium bloodstream infections seem to be an independent risk factor for poor long-term outcomes. As such, future research should confirm this relationship and prioritize investigating its causality through prospective studies.