Archives of dermatology · 2008
A retrospective analysis of patients with bullous pemphigoid treated with methotrexate.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kjellman Petra, Eriksson Hanna, Berg Peter
Аннотация
OBJECTIVES: To evaluate treatment with methotrexate in patients with bullous pemphigoid and to elucidate the reduced adverse effects compared with standard treatment with prednisone.
DESIGN: Retrospective study (January 1, 1999-December 31, 2003).
SETTING: The Department of Dermatology and Venerology, Karolinska University Hospital.
PATIENTS: A total of 138 consecutive patients with bullous pemphigoid were included and were grouped according to the treatment they received: methotrexate, prednisone, a combination of both, or topical glucocorticoids (for mild disease).
RESULT: Methotrexate was the most effective treatment, with only a few adverse effects and a tendency toward better survival rates in patients with moderate to severe disease.
CONCLUSION: Methotrexate is an effective and safe drug and provides an excellent treatment option in patients with bullous pemphigoid.
DESIGN: Retrospective study (January 1, 1999-December 31, 2003).
SETTING: The Department of Dermatology and Venerology, Karolinska University Hospital.
PATIENTS: A total of 138 consecutive patients with bullous pemphigoid were included and were grouped according to the treatment they received: methotrexate, prednisone, a combination of both, or topical glucocorticoids (for mild disease).
RESULT: Methotrexate was the most effective treatment, with only a few adverse effects and a tendency toward better survival rates in patients with moderate to severe disease.
CONCLUSION: Methotrexate is an effective and safe drug and provides an excellent treatment option in patients with bullous pemphigoid.