Environmental research · 2026
Associations of prenatal exposure to organophosphate pesticides with eczema and allergic rhinoconjunctivitis in 4-year-old children: The Japan Environment and Children's Study.
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Marsela Megasari, Iwata Hiroyoshi, Ait Bamai Yu, Itoh Mariko, Ketema Rahel Mesfin, Yamaguchi Takeshi, Saijo Yasuaki, Ito Yoshiya, Itoh Sachiko, Yamazaki Keiko, Tamura Naomi, Makino Keitaro, Tojo Maki, Kishi Reiko, Ikeda Atsuko, Japan Environment and Children's Study Group
Аннотация
PURPOSE: This study aimed to evaluate the associations of prenatal exposure to organophosphate pesticides (OPP) with eczema and allergic rhinoconjunctivitis (AR) in 4-year-old Japanese children.
METHODS: The participants in this study were Sub-Cohorts of the Japan Environment and Children's Study (JECS). The maternal urinary OPP metabolite concentrations of six dialkylphosphates (DAPs) were measured by lipid chromatography coupled with tandem mass spectrometry, corrected by specific gravity. Eczema and AR cases were defined according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for children at 4 years old. Multiple logistic regression analysis was used to examine the associations of DAPs with eczema and AR. Sub-group analyses were performed to explore the association between DAP metabolites and AR and eczema in children with elevated (≥170 IU/mL) and lower (<170 IU/mL) serum IgE levels.
RESULTS: Data from 4218 participants were analyzed. The highest DAP concentration was observed in the dimethylthiophosphate (DMTP) (Median: 3.33 ng/ml). Out of the six measured OPP metabolites, only 3 could be used for the analyses. There were positive associations of dimethylphosphate (DMP) (adjusted OR = 1.30; 95%CI = 1.06-1.59; FDR-adjusted p = 0.048) with eczema. No associations were found with AR or IgE alone. Sub-group analysis revealed a positive association between DMTP and eczema in children with lower IgE levels (<170 IU/mL) (adjusted OR = 1.28; 95%CI = 1.04-1.57; p = 0.02).
CONCLUSION: Prenatal DMP and DMTP were associated with an increased risk of eczema in children aged 4, with this association confined to children with DMTP and lower IgE levels, while no associations were found with AR or IgE levels.
METHODS: The participants in this study were Sub-Cohorts of the Japan Environment and Children's Study (JECS). The maternal urinary OPP metabolite concentrations of six dialkylphosphates (DAPs) were measured by lipid chromatography coupled with tandem mass spectrometry, corrected by specific gravity. Eczema and AR cases were defined according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for children at 4 years old. Multiple logistic regression analysis was used to examine the associations of DAPs with eczema and AR. Sub-group analyses were performed to explore the association between DAP metabolites and AR and eczema in children with elevated (≥170 IU/mL) and lower (<170 IU/mL) serum IgE levels.
RESULTS: Data from 4218 participants were analyzed. The highest DAP concentration was observed in the dimethylthiophosphate (DMTP) (Median: 3.33 ng/ml). Out of the six measured OPP metabolites, only 3 could be used for the analyses. There were positive associations of dimethylphosphate (DMP) (adjusted OR = 1.30; 95%CI = 1.06-1.59; FDR-adjusted p = 0.048) with eczema. No associations were found with AR or IgE alone. Sub-group analysis revealed a positive association between DMTP and eczema in children with lower IgE levels (<170 IU/mL) (adjusted OR = 1.28; 95%CI = 1.04-1.57; p = 0.02).
CONCLUSION: Prenatal DMP and DMTP were associated with an increased risk of eczema in children aged 4, with this association confined to children with DMTP and lower IgE levels, while no associations were found with AR or IgE levels.