[Distribution of Pseudomonas aeruginosa in experimentally infected mice (author's transl)].

The distribution of experimentally administered Pseudomonas aeruginosa was studied in germfree CF no. 1 mice, barrier-sustained DDD mice with or without oral treatment of aminobenzyl-penicillin and conventional DDD mice. On day 1 after oral administration of 8 X 10(7) organisms, more than 10(8) of organisms/g were recovered from the feces of ex-germfree mice and the number was maintained during the experiment. On the other hand, from barrier-sustained mice with antibiotic treatment and those without the treatment, 10(4-7) and 10(3) organisms were recovered, respectively. In all of monoassociated mice and some antibiotic-treated barrier-sustained ones the organisms were recovered also from the lungs, liver, spleen and kidneys. In conventional mice, however, no organisms were recovered from the internal organs throughout the experiment, while some were detectable from the intestinal tracts. The distribution of the organisms in naturally infected mice appears to be similar to that of experimentally infected animals with antibiotics.