Histiocytic medullary reticulosis in childhood.

The clinical, radiographic and pathologic findings of two children (ages 6 months and 5 1/2 years) with histiocytic medullary reticulosis are reviewed. Chest radiographs, excretory urograms, and skeletal survey revealed involvement of the mediastinum, lung parenchyma, pleural space, liver, spleen, kidneys, retroperitoneal lymph nodes, and long bones. This condition has rarely been reported in children and never during the first year of life. Histiocytic medullary reticulosis can occur in the very young; familiarity with its presentation at an early age helps to differentiate it from other infiltrative disorders of childhood.