Медицинская библиотека · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2012

In vitro atrial septal ablation using high-intensity focused ultrasound.

Takei Yasuyoshi, Muratore Robert, Kalisz Andrew, Okajima Kazue, Fujimoto Kohei, Hasegawa Takuya, Arai Kotaro, Rekhtman Yelena, Berry Grace, Di Tullio Marco R, Homma Shunichi

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

BACKGROUND

High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU.

METHODS

Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm(2) for 0.4 sec in 1-sec intervals.

RESULTS

Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R(2) = 0.3389, P < .0001) and lesion volume (R(2) = 0.6161, P < .0001).

CONCLUSIONS

HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.

Для цитирования: Takei Yasuyoshi, Muratore Robert, Kalisz Andrew, Okajima Kazue, Fujimoto Kohei, Hasegawa Takuya, Arai Kotaro, Rekhtman Yelena, Berry Grace, Di Tullio Marco R, Homma Shunichi. In vitro atrial septal ablation using high-intensity focused ultrasound.. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2012. DOI: 10.1016/j.echo.2011.12.010.

Предметные рубрики MeSH

Animals Echocardiography, Transesophageal Familial Primary Pulmonary Hypertension Feasibility Studies Heart Septum High-Intensity Focused Ultrasound Ablation Hypertension, Pulmonary In Vitro Techniques Swine Ultrasonography, Interventional

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