Nutrients · 2019
Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease.
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Simoes Ines C M, Janikiewicz Justyna, Bauer Judith, Karkucinska-Wieckowska Agnieszka, Kalinowski Piotr, Dobrzyń Agnieszka, Wolski Andrzej, Pronicki Maciej, Zieniewicz Krzysztof, Dobrzyń Paweł, Krawczyk Marcin, Zischka Hans, Wieckowski Mariusz R, Potes Yaiza
Аннотация
Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.