Stroke and vascular neurology · 2025
Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yang Qiong, Zeng Xiangzhu, Tang Lu, Liu Xiaolu, Xia Kailin, Gao Feng, Huang Xu, Li Nan, Fan Dongsheng
Аннотация
BACKGROUND AND OBJECTIVE: We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).
METHODS: We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.
RESULTS: 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, APOE ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p<0.001) after adjusting for age, and remained significant after adjusting for age and ICH volume.
CONCLUSION: In patients with spontaneous supratentorial ICH, APOE ε2 and ε4 alleles were associated with SAE and FLP, respectively, suggesting APOE allele-specific effects on CT markers of CAA and their potential mechanisms.
METHODS: We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.
RESULTS: 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, APOE ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p<0.001) after adjusting for age, and remained significant after adjusting for age and ICH volume.
CONCLUSION: In patients with spontaneous supratentorial ICH, APOE ε2 and ε4 alleles were associated with SAE and FLP, respectively, suggesting APOE allele-specific effects on CT markers of CAA and their potential mechanisms.
Предметные рубрики MeSH
HumansMaleFemaleCerebral Amyloid AngiopathyAgedMiddle AgedCerebral HemorrhageChinaPredictive Value of TestsRisk FactorsPhenotypeGenetic Predisposition to DiseaseApolipoproteins EApolipoprotein E4Cerebral AngiographyComputed Tomography AngiographyGenetic Association StudiesApolipoprotein E2Aged, 80 and over