[The inheritance of premature ventricular excitation syndrome and the evolution of its clinical course according to prospective studies].

Interest for the problem of inheritance of premature ventricular excitation syndrome (PVES) has grown significantly in the recent years due to an increase in the prevalence of paroxysmal supraventricular tachycardia and atrial fibrillation in the general population. Appearance of such cardiac arrhythmias in young people makes it necessary to include PVES in diagnostic search program. At the same time, the clinical picture of the disease may change with age and appearance of various cardiovascular pathology. A prospective study including 240 patients was undertaken to study the evolution of the clinical course of PVES. A 30-year observation showed that in 88% of PVES patients the number of forms and the degree of the severity of cardiac arrhythmias tended to grow. By the end of the study the prevalence of paroxysmal supraventricular tachycardia had decreased significantly, while the number of patients with atrial fibrillation had increased. Attacks of atrial fibrillation occurred in PVES at older age than paroxysmal tachycardia, and it was observed much more often in cases where PVES was combined with other heart diseases. Thus, the studies show that paroxysms of atrial fibrillation in PVES patients occur more often in the presence of different cardiovascular diseases, and that clinical manifestations of PVES are determined by the evolution of the associated diseases as well.