Kardiologiia · 2005
[Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation].
Сравнительное исследованиеСтатьяНазвание и аннотация: Оригинал на русском
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Shubik Iu V, Medvedev M M, Rivin A E
Аннотация
AIM: To assess efficacy of a potassium channel blocker nibentan for pharmacological cardioversion of persistent atrial fibrillation. Method. Nibentan (1% solution) was infused intravenously after 3 weeks of warfarin pretreatment to 31 patients with duration of atrial fibrillation from 4 weeks to 15 months.
RESULTS: Sinus rhythm was restored in 24 patients. Mean dose of nibentan was 0.119+/-0.02 mg/kg. Proarrhythmic effects (paroxysmal or nonsustained polymorphic ventricular tachycardia) and substantial suppression of sinus rhythm automatism were registered in 3 and 3 patients, respectively.
CONCLUSION: Nibentan is highly effective in persistent atrial fibrillation. It can be recommended for inhospital use in intensive care facilities.
RESULTS: Sinus rhythm was restored in 24 patients. Mean dose of nibentan was 0.119+/-0.02 mg/kg. Proarrhythmic effects (paroxysmal or nonsustained polymorphic ventricular tachycardia) and substantial suppression of sinus rhythm automatism were registered in 3 and 3 patients, respectively.
CONCLUSION: Nibentan is highly effective in persistent atrial fibrillation. It can be recommended for inhospital use in intensive care facilities.