Nature genetics · 2008

Multiple ADH genes are associated with upper aerodigestive cancers.

Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

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Hashibe Mia, McKay James D, Curado Maria Paula, Oliveira Jose Carlos, Koifman Sergio, Koifman Rosalina, Zaridze David, Shangina Oxana, Wünsch-Filho Victor, Eluf-Neto Jose, Levi Jose Eduardo, Matos Elena, Lagiou Pagona, Lagiou Areti, Benhamou Simone, Bouchardy Christine, Szeszenia-Dabrowska Neonilia, Menezes Ana, Dall'Agnol Marinel Mór, Merletti Franco, Richiardi Lorenzo, Fernandez Leticia, Lence Juan, Talamini Renato, Barzan Luigi, Mates Dana, Mates Ioan Nicolae, Kjaerheim Kristina, Macfarlane Gary J, Macfarlane Tatiana V, Simonato Lorenzo, Canova Cristina, Holcátová Ivana, Agudo Antonio, Castellsagué Xavier, Lowry Ray, Janout Vladimir, Kollarova Helena, Conway David I, McKinney Patricia A, Znaor Ariana, Fabianova Eleonora, Bencko Vladimir, Lissowska Jolanta, Chabrier Amelie, Hung Rayjean J, Gaborieau Valerie, Boffetta Paolo, Brennan Paul

Аннотация

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

Предметные рубрики MeSH

Adult Age Distribution Alcohol Dehydrogenase Alcohol Drinking Alcohol-Induced Disorders Case-Control Studies Esophageal Neoplasms Female Genetic Predisposition to Disease Genotype Humans Laryngeal Neoplasms Male Middle Aged Models, Biological Oropharyngeal Neoplasms Polymorphism, Single Nucleotide Risk Factors

Multiple ADH genes are associated with upper aerodigestive cancers.

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Аннотация

Предметные рубрики MeSH