MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1016/j.bbrc.2019.10.001

Медицинская библиотека · Biochemical and biophysical research communications · 2019

The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma.

Togano Tomiteru, Kim Naomi, Kim Natalie, Park Gabriel S, Park Alex K, Bennet Maura, Park Jino

СтатьяПеревод пока не подготовлен

Аннотация

AIM: AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects.

METHODS

We established BL cell lines with altered AF1q expression using lentivirus. After confirmation of gene expression by RT-PCR, cells were treated with CBD followed by co-culture of killing assay.

RESULTS

AF1q increased oncogenic growth and colony formation, and induced resistance against cell-mediated cytotoxic chemotherapy through attenuation of ICAM-1 expression in BL. CBD was able to reverse the acquired resistance mediated by AF1q/ICAM-1 regulatory axis.

CONCLUSION

CBD holds potential to enhance the efficacy of immunotherapy for BL with hyperactive AF1q/ICAM-1 regulatory axis, and warrants further study.

Для цитирования: Togano Tomiteru, Kim Naomi, Kim Natalie, Park Gabriel S, Park Alex K, Bennet Maura, Park Jino. The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma.. Biochemical and biophysical research communications. 2019. DOI: 10.1016/j.bbrc.2019.10.001.

Предметные рубрики MeSH

Breast NeoplasmsBurkitt LymphomaCannabidiolCell Line, TumorCell ProliferationCell SurvivalCoculture TechniquesDrug Resistance, NeoplasmFemaleHumansImmunotherapyIntercellular Adhesion Molecule-1LentivirusLeukocytes, MononuclearLymphocytesNeoplasm MetastasisNeoplasm ProteinsProto-Oncogene Proteins
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.